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Tubulin inhibitor 1 is an inhibitor of tubulin, inhibits tubulin polymerization, with potent anti-tumor activity, induces cellular apoptosis causes and cellular mitotic arrest in the G2/M phase.
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Tubulin inhibitor 1 is an inhibitor of tubulin, inhibits tubulin polymerization, with potent anti-tumor activity, induces cellular apoptosis causes and cellular mitotic arrest in the G2/M phase.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 482 | 5日内发货 | |
5 mg | ¥ 798 | 5日内发货 | |
10 mg | ¥ 1,590 | 5日内发货 | |
100 mg | ¥ 6,990 | 6-8周 | |
1 mL x 10 mM (in DMSO) | ¥ 888 | 5日内发货 |
产品描述 | Tubulin inhibitor 1 is an inhibitor of tubulin, inhibits tubulin polymerization, with potent anti-tumor activity, induces cellular apoptosis causes and cellular mitotic arrest in the G2/M phase. |
体外活性 | Tubulin inhibitor 1 is an inhibitor of tubulin.Tubulin inhibitor 1 has potent anti-proliferative activity against SK-OV-3, MDA-MB-231, HeLa, A549, CT26 and MCF-7 cells(IC50s of 16.7 ± 3.0, 31.4 ± 0.7, 32.8 ± 2.9, 67.0 ± 0.8, 58.0 ± 2.4 and 35.4 ± 5.6 nM, respectively). Tubulin inhibitor 1 (40, 80, and 160 nM, 48 hours) markedly causes cellular mitotic arrest in the G2/M phase, induces apoptosis in SK-OV-3 cells. |
体内活性 | In Balb/c nude mice bearing SK-OV-3 cells, Tubulin inhibitor 1 (50 mg/kg, i.p., )treatment every two days three times for 20-25 days is well tolerated, significantly reduces tumour growth . |
分子量 | 368.43 |
分子式 | C21H24N2O4 |
CAS No. | 2237054-53-2 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 125 mg/mL (339.28 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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